Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.1K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.1K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

705
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
705
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

332
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
332
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

376
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
376
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

625
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
625
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

696
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
696

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equity in Uptake of NHS and Private Optometry Services in Wales by Age and Gender.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

Burden of scrub typhus in north-eastern region of India: A systematic review and meta-regression analysis.

The Indian journal of medical research·2026
Same author

Global Survey on the Management of Multidrug-resistant Gram-negative Bacilli: Divergence of Practice Between High-Income Countries and the Rest of the World.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Plasma and Intracellular Concentrations of Doxycycline and Azithromycin in Patients with Severe Scrub Typhus.

Antibiotics (Basel, Switzerland)·2026
Same author

Anti-IFN-γ autoantibodies and disseminated opportunistic infections in immunocompetent Indian adults.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Beyond Painful Bones and Renal Stones: Acute Crystal Arthropathy of Dual Aetiology May Be an Unforeseen Complication Following Parathyroid Surgery.

Cureus·2026

Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies
04:47

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies

Published on: December 1, 2023

956

Scrub typhus: a reemerging infection.

Rebecca John1, George M Varghese

  • 1Department of Infectious Diseases, Christian Medical College, Vellore, India.

Current Opinion in Infectious Diseases
|September 2, 2020
PubMed
Summary

Scrub typhus, a neglected disease caused by Orientia tsutsugamushi, is reemerging globally. Quantitative PCR is most sensitive in early disease, while IgM ELISA and rapid tests are effective serological options.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Scrub typhus, caused by Orientia tsutsugamushi, is a neglected tropical disease with increasing global incidence.
  • Resurgence patterns are observed in both endemic and non-endemic regions, necessitating updated diagnostic and management strategies.

Purpose of the Study:

  • To comprehensively review available data on scrub typhus diagnosis and management.
  • To assist physicians in accurate diagnosis and appropriate treatment of Orientia tsutsugamushi infections.

Main Methods:

  • Review of current literature on diagnostic modalities for scrub typhus.
  • Analysis of sensitivity and specificity of various diagnostic tests, including PCR and serological assays.
  • Evaluation of current treatment guidelines for mild and severe scrub typhus.

More Related Videos

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
08:20

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

2.2K
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.1K

Related Experiment Videos

Last Updated: Dec 10, 2025

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies
04:47

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies

Published on: December 1, 2023

956
Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
08:20

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

2.2K
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.1K

Main Results:

  • Quantitative PCR demonstrates the highest sensitivity in early-stage scrub typhus (less than 7 days) when serological tests are negative.
  • IgM enzyme-linked immunosorbent assay (ELISA) and rapid diagnostic tests exhibit excellent sensitivity and specificity for scrub typhus diagnosis.
  • Doxycycline and azithromycin are effective treatments for mild scrub typhus.

Conclusions:

  • High clinical suspicion is crucial for diagnosing scrub typhus, an acute febrile illness that can lead to multi-organ dysfunction.
  • Quantitative PCR is recommended for early diagnosis, while IgM ELISA and rapid tests are reliable serological methods.
  • Further research is needed to establish optimal treatment protocols for severe scrub typhus cases.