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The role of methotrexate in osteosarcoma
J L Grem1, S A King, R E Wittes
1Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.
Journal of the National Cancer Institute
|July 6, 1988
Summary
High-dose methotrexate (MTX) is a key chemotherapy for nonmetastatic osteosarcoma. This review details MTX
Area of Science:
- Oncology
- Pharmacology
- Chemotherapy
Background:
- High-dose methotrexate (MTX) is utilized in adjuvant chemotherapy for nonmetastatic osteosarcoma.
- Understanding MTX's role is crucial for optimizing treatment strategies.
Purpose of the Study:
- To review the historical development and application of high-dose MTX in osteosarcoma treatment.
- To discuss fundamental aspects of MTX therapy in osteosarcoma.
Main Methods:
- Historical review of clinical trials involving MTX in osteosarcoma.
- Analysis of single-agent and combination chemotherapy regimens.
Main Results:
- The evolution of MTX use from initial studies to complex combinations is presented.
- Key considerations for MTX therapy in osteosarcoma are highlighted.
Conclusions:
- High-dose MTX has a significant, evolving role in nonmetastatic osteosarcoma management.
- A comprehensive understanding of MTX's history and application informs current therapeutic decisions.