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Related Experiment Video

Updated: Dec 10, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Unethical not to Investigate Radiotherapy for COVID-19.

Jerry M Cuttler1, Joseph J Bevelacqua2, S M J Mortazavi3

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Dose-Response : a Publication of International Hormesis Society
|September 2, 2020
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Low-dose whole-lung radiation therapy shows promise for improving COVID-19 pneumonia symptoms. Early trials indicate safety and efficacy, warranting further investigation as a potential treatment.

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COVID-19low dose radiationlung radiotherapypneumonia

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Radiology

Background:

  • Concerns regarding low-dose radiotherapy (LDRT) for COVID-19 patients were raised, emphasizing the need for careful evidence and logistical evaluation.
  • Clinical trials investigating LDRT for COVID-19 pneumonia commenced following ethical considerations and preliminary data.
  • The primum non nocere principle guided the cautious approach to exploring LDRT in this context.

Purpose of the Study:

  • To evaluate the safety and efficacy of low-dose whole-lung radiation in patients with COVID-19 pneumonia.
  • To assess the impact of LDRT on clinical status, encephalopathy, and radiographic findings.
  • To determine if LDRT exacerbates the cytokine storm in COVID-19 patients.

Main Methods:

  • Phase I/II clinical trial involving oxygen-dependent patients with COVID-19 pneumonia.
  • Administration of low-dose whole-lung radiation.
  • Interim analysis of day-7 results, including clinical, neurological, and radiological assessments.

Main Results:

  • Rapid improvement in clinical status observed in pilot trial participants.
  • Reduction in encephalopathy and radiographic infiltrates noted.
  • No acute toxicity or worsening of the cytokine storm reported; LDRT demonstrated safety and early promise.

Conclusions:

  • Low-dose whole-lung radiation is a potentially safe and effective therapeutic option for COVID-19 pneumonia.
  • Further large-scale prospective trials are warranted to confirm these promising preliminary findings.
  • Ethical considerations support continued investigation of radiotherapy as a remedy for COVID-19 induced pneumonia.