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Related Experiment Video

Updated: Dec 10, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2.

Yufei Xiang¹, Sham Nambulli^2,3, Zhengyun Xiao¹

¹Department of Cell Biology.

Biorxiv : the Preprint Server for Biology

|September 2, 2020

Summary

Researchers developed potent nanobodies (Nbs) targeting the SARS-CoV-2 spike protein receptor-binding domain (RBD). These nanobodies offer highly effective, cost-efficient COVID-19 therapeutics with potential to prevent viral escape.

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Last Updated: Dec 10, 2025

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Published on: April 6, 2021

Area of Science:

Biotechnology
Immunology
Structural Biology

Background:

The COVID-19 pandemic necessitates urgent development of effective and affordable therapeutics.
Existing treatments face challenges in efficacy, cost, and accessibility.

Conclusions:

Developed nanobodies represent highly potent and promising therapeutic candidates for COVID-19.
Engineered nanobody cocktails offer enhanced efficacy and a strategy against viral evolution.
These nanobodies are thermostable, cost-effective, and suitable for large-scale production and diverse delivery methods, facilitating rapid clinical translation.