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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Modeling iontophoretic drug delivery in a microfluidic device.

Maryam Moarefian¹, Rafael V Davalos, Danesh K Tafti

¹Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

|September 2, 2020

Summary

This study introduces an iontophoresis-on-chip platform for precise cancer drug delivery. Optimized electrical fields significantly enhanced carboplatin delivery and triple-negative breast cancer cell death.

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Area of Science:

Biomedical Engineering
Cancer Therapeutics
Drug Delivery Systems

Background:

Iontophoresis utilizes electrical fields for targeted drug delivery, showing promise for in vivo cancer treatment.
Precise modeling of electric fields in cell cultures is crucial for optimizing iontophoretic drug delivery to tumors.
Existing methods lack precise quantification of drug delivery and efficacy in tumor microenvironments.

Purpose of the Study:

To develop and validate an iontophoresis-on-chip (IOC) platform for precise quantification of drug delivery and anti-cancer efficacy.
To model and optimize low-intensity electric fields for iontophoretic delivery of chemotherapeutics to cancer cells.
To investigate the transport of charged drugs through extracellular matrix models using microfluidic devices.

Main Methods:

Developed a heparin-based hydrogel microfluidic device to simulate extracellular matrix and MDA-MB-231 triple-negative breast cancer cells.
Employed finite element modeling to compute drug concentration based on diffusion and electrophoresis.
Validated the IOC platform by comparing predicted fluorescent dye concentrations with actual measurements.

Main Results:

A 50 mV DC electric field and 3 mA current significantly enhanced carboplatin delivery.
Demonstrated a significant increase in tumor cell death (39.13% ± 12.86) with optimized iontophoresis.
Model predictions for drug transport were validated using the IOC platform with fluorescent dye.

Conclusions:

The IOC platform and mathematical model offer a promising approach for precise chemotherapeutic drug delivery to solid tumors.
Optimized iontophoretic parameters can significantly improve drug delivery efficiency and cancer cell killing.
Further development of the IOC platform could incorporate epidermal cell layers for more comprehensive skin modeling.