Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Captopril overdose resulting in hypotension.

W L Augenstein1, K W Kulig, B H Rumack

  • 1Rocky Mountain Poison and Drug Center, Denver, CO 80204.

JAMA
|June 10, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.

Human & experimental toxicology·2018
Same author

A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.

American journal of therapeutics·2001
Same author

Assessment and reporting of clinical pharmacology information in drug labeling.

Clinical pharmacology and therapeutics·2000
Same author

Acetaminophen overdose? A quick answer.

The Journal of pediatrics·1999
Same author

Hydrogen sulfide poisoning: an antidotal role for sodium nitrite?

Veterinary and human toxicology·1997
Same journal

Alcohol-Related Liver Disease: A Review.

JAMA·2026
Same journal

Online Prescribing of GLP-1 Receptor Agonists.

JAMA·2026
Same journal

Using AI Disagreement to Expose Gaps in Coverage Rules.

JAMA·2026
Same journal

Randomized Trials in Pregnancy.

JAMA·2026
Same journal

Randomized Trials in Pregnancy-Reply.

JAMA·2026
Same journal

WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

JAMA·2026
See all related articles

This case report details a severe captopril overdose, an angiotensin converting enzyme inhibitor, leading to persistent hypotension. The patient required repeated interventions to manage blood pressure following the overdose.

Area of Science:

  • Pharmacology
  • Toxicology
  • Cardiology

Background:

  • Captopril, an angiotensin converting enzyme inhibitor, is used for hypertension and heart failure.
  • Overdose of captopril can lead to significant adverse effects.
  • Concurrent overdose with alprazolam can complicate management.

Observation:

  • A patient presented with severe hypotension (systolic BP 80 mm Hg) and drowsiness after a suicide attempt involving captopril and alprazolam.
  • Hypotension recurred twice at 18.5 and 24.5 hours post-ingestion, requiring repeated fluid and dopamine administration.
  • A high plasma captopril level (27,391.1 nmol/L) and depressed angiotensin converting enzyme levels were documented.

Findings:

  • This is the first reported case of acute captopril overdose in English literature.

Related Experiment Videos

  • The patient's hypotension was refractory and recurrent, responding temporarily to vasopressors.
  • The study highlights the prolonged hypotensive effect of a massive captopril overdose.

    • Implications:

    • This case underscores the potential for severe and prolonged hypotension following captopril overdose.
    • Understanding the pharmacodynamics of captopril in overdose is crucial for clinical management.
    • Further research into the management of ACE inhibitor overdose is warranted.