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Updated: Dec 10, 2025

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Platelets in aging and cancer-"double-edged sword".

Alessandra V S Faria1,2, Sheila S Andrade3, Maikel P Peppelenbosch1

  • 1Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, NL-3000 CA, Rotterdam, The Netherlands.

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Summary

Aging platelets influence cardiovascular disease and cancer metastasis. Understanding these changes is crucial for developing healthy aging strategies and improving treatments for thrombosis and cancer progression.

Keywords:
AgingCancerPlatelet functionPlatelet reactivity

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Area of Science:

  • Hematology
  • Gerontology
  • Oncology

Background:

  • Platelets are vital for hemostasis, inflammation, and immunity.
  • Platelet function can be altered by aging, impacting age-related diseases.
  • Platelet activity is implicated in cardiovascular disease, cancer metastasis, and venous thromboembolism (VTE).

Purpose of the Study:

  • To review age-related changes in platelet function.
  • To investigate the role of platelets in cancer progression.
  • To inform healthy aging strategies and therapeutic interventions.

Main Methods:

  • Literature review of platelet function and aging.
  • Analysis of platelet involvement in cardiovascular disease.
  • Examination of platelet contributions to cancer metastasis and VTE.

Main Results:

  • Platelet function undergoes significant changes with aging.
  • Altered platelets contribute to the development of age-related pathologies.
  • Platelets play a multifaceted role in cancer cell metastasis and thrombosis.

Conclusions:

  • Understanding age-associated platelet alterations is key to addressing major health challenges.
  • Targeting platelet function may offer new therapeutic avenues for aging-related diseases.
  • Further research into platelet biology during aging can advance healthy aging initiatives.