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Laboratory Assessment of Coagulation Factor XIII
1Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Hamostaseologie
|September 2, 2020
Summary
Diagnosing factor XIII (FXIII) deficiency is difficult due to assay limitations. This review covers FXIII assay methods, challenges, and diagnostic strategies for suspected FXIII deficiencies.
Area of Science:
- Hematology
- Clinical Chemistry
Background:
- Congenital and acquired deficiencies of coagulation factor XIII (FXIII) present diagnostic challenges.
- Accurate FXIII function determination relies on specific and sensitive assays, which are not universally accessible.
Purpose of the Study:
- To review current laboratory methods for diagnosing FXIII deficiency.
- To discuss the principles, difficulties, and recommended diagnostic workup for FXIII deficiency.
- To briefly mention experimental methods in FXIII research.
Main Methods:
- Literature review of FXIII assay methodologies.
- Analysis of principles and limitations of existing diagnostic tests.
- Discussion of recommended diagnostic algorithms.
Main Results:
- Current FXIII assay methods vary in specificity and sensitivity.
- Several challenges exist in the routine laboratory diagnosis of FXIII deficiency.
- A structured diagnostic approach is essential for accurate identification of FXIII deficiency.
Conclusions:
- Improved and standardized FXIII assays are needed for reliable diagnosis.
- A clear diagnostic workup pathway is crucial for patients with suspected FXIII deficiency.
- Further research into experimental methods may offer future diagnostic advancements.
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