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Ethnic Disparities in Atherosclerotic Cardiovascular Disease Incidence and Prevalence Among Rheumatoid Arthritis

Christina M Daniel1, Lesley Davila1, Una E Makris2

  • 1University of Texas Southwestern Medical Center, Dallas, Texas.

ACR Open Rheumatology
|September 2, 2020
PubMed

Insights

This review found limited data on atherosclerotic cardiovascular disease (ASCVD) in diverse rheumatoid arthritis (RA) populations. More research is needed to understand ASCVD risk across racial and ethnic groups with RA.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Rheumatoid arthritis (RA) is linked to higher rates of atherosclerotic cardiovascular disease (ASCVD).
  • General population studies show racial/ethnic disparities in cardiovascular disease (CVD) prevalence, but reasons remain unclear.
  • Understanding these disparities within the RA population is crucial for targeted interventions.

Purpose of the Study:

  • To systematically review and describe the incidence and prevalence of ASCVD stratified by race/ethnicity within the US rheumatoid arthritis (RA) population.
  • To identify existing data gaps regarding ASCVD outcomes in diverse RA patient groups.

Main Methods:

  • Searched MEDLINE, Embase, and Cochrane databases for studies on ASCVD incidence/prevalence in RA patients.
  • Included studies reporting fatal/nonfatal stroke, myocardial infarction, or cardiovascular death.
  • Two reviewers screened abstracts and full texts, with a third resolving discrepancies.

Main Results:

  • Screened 2625 abstracts; 138 manuscripts were fully reviewed, with 21 included studies.
  • No studies initially stratified ASCVD by race/ethnicity in RA patients.
  • Average prevalent ASCVD in RA is 46.9%; average incident ASCVD is 8.2%.

Conclusions:

  • A significant lack of data exists on racially/ethnically diverse rheumatoid arthritis patients and their ASCVD outcomes.
  • Future research must stratify ASCVD prevalence by race/ethnicity in US RA populations.
  • Such data are essential for clinicians to effectively manage cardiovascular disease risk in RA patients.
Abstract

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