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Updated: Dec 10, 2025

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
Published on: October 31, 2012
[Surgical treatment of post-burn defects of face and calvaria]
P V Sarygin1,2,3, S V Popov2, S A Ukhin1
1Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.
Objective:
To evaluate the effectiveness of surgical treatment of post-burn defects of face and cranial vault.
Material And Methods:
There were 65 patients with post-burn defects of face and cranial vault. Mean age of patients was 38.5 years (min 17 years, max 67 years). Soft tissue reconstruction was performed by using of local tissues, combined plasty, balloon dermotension aand free flaps on microvascular anastomoses. Osteoectomy and sequestrectomy were carried out if it was necessary. Implants were used to eliminate through skull defects.
Results:
Balloon dermotension with expanders and plasty with local tissues ensure skull reconstruction in the vast majority of patients. Through bone defects required reconstruction of the cranial vault with various implants.
Conclusion:
The proposed surgical approach ensures correction of severe functional and cosmetic disorders caused by post-burn skull defects, elimination of bone damage, restoration of normal skin of the face and cranial vault.
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09:07Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
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