Related Experiment Video

Updated: Dec 10, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

17.0K

Pediatric and young adult renal cell carcinoma

Satyajit Ray1, Robert Jones2, Kathy Pritchard-Jones3

  • 1Department of Paediatric Oncology, Royal Hospital for Children, Glasgow, Scotland, UK.

Pediatric Blood & Cancer
|September 2, 2020
PubMed

Insights

Pediatric renal cell carcinoma (RCC) differs from adult disease, with surgery being key for localized cases. Current treatments lack efficacy for metastatic disease, though sunitinib shows promise.

Area of Science:

  • Oncology
  • Pediatric Nephrology
  • Cancer Research

Background:

  • Renal cell carcinoma (RCC) is uncommon in children but prevalent in adults.
  • Pediatric RCC exhibits distinct clinical, histopathological, and therapeutic features compared to adult RCC.
  • Existing literature lacks comprehensive reviews on pediatric RCC management and outcomes.

Purpose of the Study:

  • To provide an overview of pediatric renal cell carcinoma (RCC).
  • To summarize current understanding of pediatric RCC characteristics, treatment, and outcomes.
  • To explore the emerging role of precision medicine in pediatric RCC.

Main Methods:

  • Systematic review of databases from inception to February 2020.
  • Identification and analysis of 32 publications involving 350 patients under 27 years old.
  • Synthesis of data on clinical presentation, histopathology, treatment modalities, and outcomes.

Main Results:

  • Surgery is the primary curative treatment for localized pediatric RCC.
  • Conventional radiotherapy and chemotherapy show limited efficacy in pediatric RCC.
  • Pediatric metastatic RCC has a poor prognosis, with limited evidence supporting adjuvant therapies like sunitinib.

Conclusions:

  • Pediatric RCC requires tailored management strategies distinct from adult protocols.
  • Further research, including prospective studies, is needed to optimize adjuvant therapies.
  • Precision medicine approaches hold potential for improving outcomes in pediatric RCC.

Keywords:
pediatricsrenal cell carcinomatargeted therapytreatment

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.0K
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.0K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
131
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.3K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
2.7K
Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
567
Renal Drug Excretion: Tubular Reabsorption01:25

Renal Drug Excretion: Tubular Reabsorption

Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
554