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Related Experiment Video

Updated: Dec 10, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented

Yeow Hoay Koh1, Yao-Chia Shih2,3, Soo Lee Lim2

  • 1Department of Neurology, National Neuroscience Institute - Outram Campus, 20 College Road, Singapore, 169856, Singapore.

European Radiology
|September 2, 2020
PubMed
Summary

Simultaneous multi-slice (SMS) imaging with readout-segmented echo planar imaging (RESOLVE-DTI) allows for fast and reliable diffusion tensor imaging of the trigeminal nerve. This technique shows potential for improved clinical management of trigeminal neuralgia.

Keywords:
Diffusion tensor imagingEcho planar imagingTrigeminal nerve diseasesTrigeminal neuralgia

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Area of Science:

  • Neuroimaging
  • Diffusion Tensor Imaging

Background:

  • Readout-segmented echo planar imaging (RESOLVE-DTI) minimizes posterior fossa artifacts but has long acquisition times.
  • Simultaneous multi-slice (SMS) imaging accelerates MRI scans, but its effect on cranial nerve DTI in the skull base is unknown.

Purpose of the Study:

  • To evaluate the reliability of trigeminal nerve DTI metrics using SMS combined with RESOLVE-DTI.
  • To assess the impact of SMS acceleration on DTI data quality and consistency.

Main Methods:

  • Three RESOLVE-DTI protocols were compared in 8 healthy controls and 6 trigeminal neuralgia patients: non-SMS, SMS with identical TR, and SMS with short TR.
  • Trigeminal nerve streamlines were tracked, and DTI metrics were analyzed for signal-to-noise ratio (SNR) and reliability using intraclass correlation coefficients (ICCs).

Main Results:

  • No visual artifacts were observed in the trigeminal nerves across all protocols.
  • Pontine SNR was highest in non-SMS, but SMS protocols showed comparable results.
  • Intra-rater and inter-rater ICCs were excellent (>0.85), indicating high reliability.
  • SMS and non-SMS protocols yielded consistent DTI metrics with significant linear relationships.

Conclusions:

  • SMS RESOLVE-DTI provides a fast and reliable method for assessing trigeminal nerve microstructural integrity.
  • This technique has potential clinical applications in managing trigeminal neuralgia.
  • Two-fold accelerated RESOLVE-DTI offers comparable results, significantly reducing scan time.