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[Familial acanthosis nigricans].

M Casado Jimenez1, J Borbujo Martinez, F Jimenez Acosta

  • 1Facultad de Medicina, Servicio de Dermatología, Hospital La Paz, Universidad Autónoma de Madrid.

Medicina Cutanea Ibero-Latino-Americana
|January 1, 1988
PubMed
Summary

Familial acanthosis nigricans presents with skin lesions starting in childhood and affecting multiple family members. This case highlights key features distinguishing it from other benign forms of acanthosis nigricans.

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Area of Science:

  • Dermatology
  • Genetics
  • Clinical Medicine

Background:

  • Acanthosis nigricans is a skin condition characterized by hyperpigmentation and thickening of skin folds.
  • It can be associated with various underlying conditions, including endocrine disorders and malignancies, or be inherited.
  • Understanding its diverse presentations is crucial for accurate diagnosis and management.

Observation:

  • Presents a clinical case of familial acanthosis nigricans.
  • The affected individual experienced onset of lesions in childhood.
  • Three other family members were also diagnosed with the condition.

Findings:

  • The familial form of acanthosis nigricans exhibits distinct characteristics.
  • These features aid in differentiating it from other benign variants of the condition.

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  • Detailed clinicopathological findings are discussed.

    • Implications:

    • Accurate classification of acanthosis nigricans subtypes is essential for appropriate patient care.
    • Recognizing the familial pattern can guide genetic counseling and family screening.
    • This case contributes to the understanding of hereditary dermatological conditions.