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Updated: Dec 10, 2025

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
Published on: November 21, 2025
Effectiveness of an alternative intervention in the treatment of depressive symptoms
Leandro Cardozo-Batista1, Adriana Marcassa Tucci2
1Interdisciplinary Health Sciences Program, Federal University of São Paulo, Brazil.
Background:
There is a scarcity of studies in the international literature regarding alternative treatment to the pharmacological and psychotherapeutic intervention in the face of depression symptoms. This study aimed to test a protocol based on natural therapy, alternatives to pharmacological and psychotherapeutic, through Mindfulness Meditation, Reiki, Acupuncture and Auriculotherapy, to treat the symptoms of depression for those who were with no pharmacological or psychotherapeutic treatment for these symptoms.
Methods:
this is a randomized single-blind controlled pilot study. The final sample was 21 participants divided in two groups: experimental and control. Participants were evaluated by validated instruments during the screening process and after the intervention. The instruments were: Depression, Anxiety and Stress Scale and Beck Depression Inventory. Intervention was performed in eight sessions, during two months. All the techniques were used in the experimental group. Analysis of variance with repeated measures was used to compare pre-intervention to post-intervention moments.
Results:
the result of analysis indicates a significant reduction in the symptoms of depression after the intervention among the experimental group.
Limitations:
there is no way to determine which of the techniques used produced the most significant result.
Conclusions:
The protocol proposed in this study was effective in reducing the symptoms of depression to whom are not eligible for traditional treatment.
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