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Updated: Dec 10, 2025
Author Spotlight: Advancing Traumatic Brain Injury Research - A Closed-Head Model for Accurate Replication and Rapid Assessment
Published on: September 22, 2023
The Effect of Rutin on Experimental Traumatic Brain Injury and Edema in Rats
Sahin Yuceli1, Gulce Naz Yazici2, Renad Mammadov3
1Department of Neurosurgery, Neon Hospital, Erzincan, Turkey.
Background/Aim:
The aim of the study was to evaluate the effect of rutin, which is a vitamin P1 flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats.
Materials And Methods:
Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically.
Results:
We found that the levels of malondialdehyde, nuclear factor-kappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema.
Conclusion:
Rutin might be effective in the treatment of TBI and TBI-related brain edema.
