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Updated: Dec 10, 2025
Cryosectioning Method for Microdissection of Murine Colonic Mucosa
Published on: July 12, 2015
Preliminary Report: Asymmetric Crypt Fission in Biopsies from Patients With Ulcerative Colitis
Carlos A Rubio1, Peter T Schmidt2
1Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Centre for Digestive Diseases, Stockholm, Sweden Carlos.Rubio@ki.se.
Background:
Recently, we found crypts with asymmetric fission bordering ulcers in colectomy specimens from patients with ulcerative colitis (UC). Here, we report crypts with asymmetric fission found in biopsies from patients with UC.
Patients And Methods:
Sections from endoscopic biopsies from five patients with UC were reviewed. The number of transected (cut-across) crypts in symmetric and asymmetric fission was assessed in sections from three biopsies in each patient.
Results:
A total of 89 crypts in fission were recorded in the 15 biopsies; 36 (40.4%) were in symmetric fission and the remaining 53 (59.6%) in asymmetric fission.
Conclusion:
A high frequency of asymmetric crypts in fission was demonstrated in endoscopic biopsies from patients with UC. It is suggested that this previously unaddressed histological parameter is included in pathological descriptions of endoscopic biopsies from patients with UC.
