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Traditional Chinese medicine for corona virus disease 2019: A protocol for systematic review
Ju Huang1, Liu Wu2, Xiaodan Ren3
1College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine.
Insights
This systematic review protocol assesses Traditional Chinese Medicine (TCM) for treating COVID-19 patients. Evidence will determine TCM
Area of Science:
- Integrative Medicine
- Infectious Diseases
- Evidence-Based Practice
Background:
- COVID-19 poses a significant global health challenge.
- Traditional Chinese Medicine (TCM) has been explored as a complementary treatment for various diseases.
- Assessing TCM's efficacy and safety in COVID-19 requires rigorous systematic evaluation.
Purpose of the Study:
- To systematically review and synthesize evidence on the effectiveness and safety of Traditional Chinese Medicine (TCM) for COVID-19 patients.
- To evaluate the impact of TCM interventions on key clinical outcomes in COVID-19.
Main Methods:
- Comprehensive search of multiple electronic databases (e.g., PubMed, EMBASE, Cochrane) from inception to April 2020.
- Inclusion of all published randomized controlled trials (RCTs) in English or Chinese.
- Independent data extraction and risk of bias assessment by two reviewers, with data synthesis using Review Manager Software V.5.2.
Main Results:
- The synthesis will provide high-quality evidence on TCM's role in managing COVID-19.
- Results will focus on symptom resolution, viral clearance, and clinical recovery metrics.
- Analysis will cover outcomes such as symptom disappearance time, cytokine levels, hospitalization duration, and mortality rates.
Conclusions:
- This systematic review will offer crucial evidence regarding the effectiveness of Traditional Chinese Medicine as an intervention for COVID-19.
- Findings will inform clinical decision-making and future research directions in integrating TCM for viral respiratory illnesses.
Background:
Assessing the effectiveness and safety of Traditional Chinese medicine for treating patients with corona virus disease 2019 (COVID-19) is the main purpose of this systematic review protocol.
Methods:
The following electronic databases will be searched from inception to April 2020: Cochrane Central Register of Controlled Trials, PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure, Traditional Chinese Medicine, Chinese Biomedical Literature Database, Wan-Fang Database, and Chinese Scientific Journal Database. All published randomized controlled trials in English or Chinese related to Traditional Chinese medicine for COVID-19 will be included. Primary outcomes are time of disappearance of main symptoms and serum cytokine levels. Secondary outcomes is Accompanying symptoms disappear rate, negative COVID-19 results rate on 2 consecutive occasions CT image improvement, average hospitalization time, occurrence rate of common type to severe form, clinical cure rate, and mortality. Two reviewers will conduct the study selection, data extraction, and assessment independently. The assessment of risk of bias and data synthesis will be conducted with Review Manager Software V.5.2.
Results:
The results will provide a high-quality synthesis of current evidence for researchers in this subject area.
Conclusion:
The conclusion of our study will provide evidence to judge whether traditional Chinese medicine is an effective intervention for COVID-19 patients.
Prospero Registration Number:
CRD42020181006.
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