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Association between ABO blood groups and risk of coronavirus disease 2019: A protocol for systematic review and

Nanyang Liu1, Tingting Zhang2, Lina Ma1

  • 1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing.

Medicine
|September 3, 2020
PubMed

Insights

This systematic review investigates the link between ABO blood groups and COVID-19 pneumonia susceptibility. Findings will clarify the role of blood type in SARS-CoV-2 infection risk.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Genetics

Background:

  • The COVID-19 pandemic has caused global health crises.
  • Emerging research suggests a link between ABO blood groups and COVID-19 susceptibility, but findings are conflicting.
  • This study aims to clarify the association between ABO blood groups and COVID-19 pneumonia.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies.
  • To evaluate the impact of ABO blood group on COVID-19 pneumonia.
  • To provide high-quality evidence on this association.

Main Methods:

  • Comprehensive literature search across multiple databases (PubMed, Embase, Web of Science, etc.) up to June 30, 2020.
  • Manual search for gray literature.
  • Data extraction, risk of bias assessment, and meta-analysis using odds ratios and confidence intervals.
  • Publication bias assessed using Begg and Egger tests.

Main Results:

  • Pooled results will be presented using forest plots.
  • Statistical heterogeneity will be evaluated using chi-squared tests and I index.
  • Odds ratios and 95% confidence intervals will quantify the association.

Conclusions:

  • This systematic review and meta-analysis will offer robust evidence.
  • The findings will elucidate the contribution of ABO blood groups to COVID-19 pneumonia.
  • Results will aid in understanding disease susceptibility factors.
Abstract

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