Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological
Erika Ferrari1, Cecilia Palma1, Simone Vesentini1
1Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milano, Italy.
Biosensors
|September 3, 2020
Summary
This review explores integrating biosensors into organs-on-chip (OoC) for real-time monitoring. These advanced microphysiological systems (MPS) offer improved tissue engineering and drug screening capabilities.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Cellular Biology
Background:
- Organs-on-chip (OoC), or microphysiological systems (MPS), mimic human organ functions for advanced research.
- Current off-chip methods limit real-time monitoring of these complex in vitro models.
- Integrated biosensing is essential for assessing OoC functionality and performance.
Purpose of the Study:
- To review recent advancements in miniaturizing and embedding biosensors into OoC platforms.
- To evaluate biosensor strategies for monitoring diverse OoC models.
- To discuss multisensor integration for multiorgan systems.
Main Methods:
- Literature review of biosensor integration techniques in OoC.
- Analysis of biosensors for metabolic, barrier, and electromechanical functions.
- Discussion of multi-organ platform sensor integration.
Main Results:
- Miniaturized biosensors can be effectively embedded within OoC.
- Various biosensing strategies enable real-time monitoring of OoC functions.
- Multisensor integration is progressing for complex multi-organ systems.
Conclusions:
- Integrated biosensors are crucial for advancing OoC technology.
- Real-time monitoring enhances the utility of OoC in drug screening and tissue engineering.
- Future research should focus on sophisticated multisensor systems for OoC.
