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Related Experiment Videos

Opiate antagonists and rewarding brain stimulation.

G J Schaefer1

  • 1Department of Psychiatry, Emory University School of Medicine, Georgia Mental Health Institute, Atlanta 30306.

Neuroscience and Biobehavioral Reviews
|January 1, 1988
PubMed
Summary

Opiate antagonists like naloxone can reliably reduce brain stimulation reward responses under specific conditions. This suggests endogenous opioids interact with dopamine systems to control reward pathways.

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Reward Systems

Background:

  • Intracranial self-stimulation (ICSS) is a key model for studying reward.
  • Endogenous opioids are hypothesized to modulate ICSS.
  • Opiate antagonists, such as naloxone, are used to investigate opioid system involvement.

Purpose of the Study:

  • To review the effects of opiate antagonists on ICSS.
  • To determine if endogenous opioids modulate ICSS reward.
  • To clarify the role of opioid and dopamine systems in ICSS.

Main Methods:

  • Literature review of studies using opiate antagonists in ICSS paradigms.
  • Analysis of naloxone's effects on response rates and agonist/stimulant effects.
  • Examination of results under different reinforcement schedules.

Main Results:

  • Naloxone produced inconsistent results in some ICSS paradigms.
  • Naloxone reliably reduced responding under intermittent reinforcement schedules.
  • Naloxone reversed opiate agonist effects and attenuated stimulant effects.

Conclusions:

  • Naloxone's effects support a modulatory role for endogenous opioids in reward.
  • Opiate and dopamine systems appear to co-regulate ICSS.
  • Further research is needed to fully understand antagonist actions and opioid modulation of reward.

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