Related Experiment Video
Updated: Dec 10, 2025
11:19
Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
Published on: October 9, 2016
15.3K
Involvement of STAT5 in Oncogenesis
Clarissa Esmeralda Halim1, Shuo Deng1, Mei Shan Ong1
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Biomedicines
|September 3, 2020
Summary
Signal transducer and activator of transcription 5 (STAT5) signaling is increasingly important in cancer, promoting cell proliferation and metastasis. Inhibiting STAT5 activation offers a promising targeted treatment option for aggressive cancers.
Area of Science:
- Oncology
- Molecular Biology
- Signal Transduction
Background:
- Signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are known to be involved in cancer.
- STAT5 signaling is increasingly recognized for its role in cancer pathology.
- STAT5 is vital for mammary gland development and immune system homeostasis.
Purpose of the Study:
- To review the role of STAT5 signaling in cancer.
- To discuss the therapeutic potential of targeting STAT5 in cancer treatment.
Main Methods:
- Literature review of STAT5 signaling in various cancers.
- Analysis of STAT5 target genes and their role in tumorigenesis.
- Overview of current and potential therapeutic strategies targeting STAT5.
Main Results:
- Aberrant STAT5 signaling drives cancer progression by promoting target gene expression (e.g., cyclin D, Bcl-2, MMP-2).
- This aberrant signaling leads to increased cell proliferation, survival, and metastasis.
- STAT5 contributes significantly to tumor aggressiveness and cancer progression.
Conclusions:
- Targeting constitutive STAT5 activation is a promising therapeutic strategy for cancers reliant on this pathway.
- STAT5 inhibitors or upstream tyrosine kinase inhibitors (TKIs) can be utilized to block STAT5 signaling.
- Inhibiting STAT5 offers a potential targeted treatment for aggressive cancers.
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
11.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.2K
03:03mTOR Signaling and Cancer Progression
4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.5K
02:23Abnormal Proliferation
5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
01:33Cancer-Critical Genes I: Proto-oncogenes
10.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.9K
01:22PI3K/mTOR/AKT Signaling Pathway
5.0K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.0K
01:06Induced Pluripotent Stem Cells
5.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
5.1K