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Cyclo(His-Pro): its distribution, origin and function in the human.

C Prasad1

  • 1Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.

Neuroscience and Biobehavioral Reviews
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Cyclo(His-Pro), a cyclic dipeptide found in the human body, may play a physiological role. Its levels in blood and cerebrospinal fluid change with health and disease, suggesting biological significance.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Endocrinology

Background:

  • Cyclo(His-Pro) (histidyl-proline diketopiperazine) is an endogenous cyclic dipeptide present in human bodily fluids and tissues.
  • Its presence is noted in blood, CSF, semen, brain, spinal cord, and the GI tract.

Purpose of the Study:

  • To investigate the physiological relevance and potential origins of cyclo(His-Pro).
  • To understand the fluctuations of cyclo(His-Pro) levels in relation to health and disease states.

Main Methods:

  • Analysis of cyclo(His-Pro) presence in various human biological samples.
  • Investigation of potential peptide precursors and enzymatic pathways involved in its synthesis.
  • Monitoring of cyclo(His-Pro) levels in blood and CSF under different physiological and pathological conditions.

Related Experiment Videos

Main Results:

  • Cyclo(His-Pro) is confirmed as an endogenous molecule in humans.
  • A portion of cyclo(His-Pro) is derived from thyrotropin-releasing hormone via Pyroglutamate aminopeptidase.
  • The precise biosynthetic pathway for the entire peptide remains speculative.
  • Observed fluctuations in blood and CSF cyclo(His-Pro) levels correlate with health and disease.

Conclusions:

  • Cyclo(His-Pro) exhibits characteristics of a physiologically active endogenous molecule.
  • Further research is warranted to elucidate its complete biosynthetic origin and specific functions.