Metal-Organic-Framework FeBDC-Derived Fe₃O₄ for Non-Enzymatic Electrochemical Detection of Glucose

Present-day science indicates that developing sensors with excellent sensitivity and selectivity for detecting early signs of diseases is highly desirable. Electrochemical sensors offer a method for detecting diseases that are simpler, faster, and more accurate than conventional laboratory analysis methods. Primarily, exploiting non-noble-metal nanomaterials with excellent conductivity and large surface area is still an area of active research due to its highly sensitive and selective catalysts for electrochemical detection in enzyme-free sensors. In this research, we successfully fabricate Metal-Organic Framework (MOF) FeBDC-derived Fe₃O₄ for non-enzymatic electrochemical detection of glucose. FeBDC synthesis was carried out using the solvothermal method. FeCl₂.4H₂O and Benzene-1,4-dicarboxylic acid (H₂BDC) are used as precursors to form FeBDC. The materials were further characterized utilizing X-ray Powder Diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier-Transform Infrared Spectroscopy (FTIR). The resulting MOF yields good crystallinity and micro-rod like morphology. Electrochemical properties were tested using Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) with a 0.1 M of Phosphate Buffer Saline (PBS pH 7.4) solution as the supporting electrolyte. The measurement results show the reduction and oxidation peaks in the CV curve of FeBDC, as well as Fe₃O₄. Pyrolysis of FeBDC to Fe₃O₄ increases the peak of oxidation and reduction currents. The Fe₃O₄ sample obtained has a sensitivity of 4.67 µA mM^-1.cm^-2, a linear range between 0.0 to 9.0 mM, and a glucose detection limit of 15.70 µM.