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Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
Sanghoon Lee1,2, Naonobu Tanaka1, Sakura Takahashi1
1Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Abstract:
Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while 3-5 were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, or N-methylated aminoimidazole moieties.
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