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Related Experiment Video

Updated: Dec 10, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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Catheter-based Arterial Input Function Determination for Myocardial Perfusion Measurements.

Simon Stephan¹, Simon Reiss¹, Thomas Lottner¹

¹Department of Radiology - Medical Physics, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Zeitschrift Fur Medizinische Physik

|September 3, 2020

Summary

This study presents a novel catheter-based method for measuring the arterial input function (AIF) during cardiovascular interventions. This technique enables accurate myocardial perfusion quantification, potentially speeding up assessments during procedures.

Keywords:

Active tracking catheter Arterial input function Interventional MRI Intra-arterial injection Myocardial perfusion

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Last Updated: Dec 10, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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Area of Science:

Cardiovascular Imaging
Medical Physics
Interventional Radiology

Background:

Accurate myocardial perfusion quantification relies on precise arterial input function (AIF) determination.
Current AIF measurement methods can be time-consuming and may not be optimal for real-time interventional guidance.

Purpose of the Study:

To evaluate an MR-guided method for determining the AIF using an active tracking catheter during targeted contrast agent (CA) injection.
To assess the feasibility and accuracy of catheter-based AIF measurements for myocardial perfusion quantification.

Main Methods:

A phantom experiment using a dialysis filter was conducted to measure AIF with an active catheter and dynamic MR imaging.
Correction methods were developed to address dilution and coil sensitivity effects for catheter-based AIF.
Quantitative perfusion maps were calculated via deconvolution and normalized using flow measurements.

Main Results:

Catheter-based and imaging-based AIF measurements showed agreement in signal-time curves, with a scaling factor difference of approximately 9.
After normalization to surrounding flow, both perfusion quantification techniques demonstrated excellent agreement.
Catheter-based AIF measurement is feasible but requires normalization via flow measurement.

Conclusions:

Catheter-based AIF measurement is a viable approach for myocardial perfusion quantification during cardiovascular interventions.
This technique, after normalization, provides results comparable to imaging-based methods.
The method holds potential for enabling faster perfusion assessments in interventional settings.