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Updated: Dec 10, 2025

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Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
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Temporal considerations in contact lens discomfort
Eric B Papas1, Annie Chiem1, George Zhang1
1School of Optometry & Vision Science, University of New South Wales, Sydney, Australia.
Summary
Contact lens wear duration, not start time, significantly increases ocular discomfort. This discomfort varies among individuals and doesn't fully explain why lenses become uncomfortable over time.
Area of Science:
- Ophthalmology
- Vision Science
- Ocular Surface Disease
Background:
- Ocular discomfort is a common complaint among contact lens wearers.
- Understanding factors contributing to discomfort is crucial for improving wearer experience and compliance.
Purpose of the Study:
- To investigate the independent contributions of contact lens wearing time and wear initiation time to perceived ocular discomfort.
- To analyze these factors within a realistic daily wear framework.
Main Methods:
- Twenty-three participants rated ocular discomfort on a visual analogue scale over 12 hours.
- Data was collected on one non-lens day and three soft contact lens wear days with varying start times.
- The change in discomfort over the wearing period was assessed in relation to wear initiation time.
Main Results:
- Contact lens wear significantly increased ocular discomfort regardless of wear start time (p < 0.01).
- No statistically significant differences in discomfort increase were found between different wear start times (p = 0.98).
- Average discomfort increase ranged from 16.8 to 23.5 over 12 hours of lens wear.
Conclusions:
- Ocular discomfort during contact lens wear is primarily linked to the duration the lenses are worn, not the time of day they are inserted.
- The variability in discomfort suggests other unmeasured factors influence wearer experience.
- Compliance monitoring is recommended for studies involving time-sensitive outcomes in contact lens wear.
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