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A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activity in vivo
Yuyao Li1, Heng Song1, Chenghong Xue1
1State Key Laboratory of Bioreactor Engineering , Shanghai Key Laboratory of New Drug Design , School of Pharmacy , East China University of Science and Technology , Shanghai 200237 , P. R. China .
Abstract:
Reported herein is a self-immobilizing near-infrared fluorogenic probe that can be used to image extracellular enzyme activity in vivo. Using a fluorophore as a quinone methide precursor, this probe covalently anchors at sites of activation and greatly enhances the fluorescence intensity at 710 nm upon enzymatic stimulus, significantly boosting detection sensitivity in a highly dynamic in vivo system.
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