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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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Dermatofibrosarcoma protuberans associated with trauma: A case report.

Robyn Cabral¹, Matthaus Wilford¹, Michael J Ramdass^2,3

¹Department of Intensive Care and Anaesthetics, Arima General Hospital, Port-of-Spain, Trinidad, West Indies.

Molecular and Clinical Oncology

|September 3, 2020

Summary

Dermatofibrosarcoma protuberans (DFSP), a rare skin cancer, may be linked to blunt trauma. This study presents a case and reviews literature suggesting trauma could play a role in DFSP development.

Keywords:

dermatofibrosarcoma protuberans

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Last Updated: Dec 10, 2025

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing soft tissue sarcoma.
DFSP typically presents on the trunk and upper extremities with low to intermediate malignancy potential.
It is characterized by significant local invasion and high recurrence rates.

Purpose of the Study:

To present a case of DFSP in a young female associated with blunt trauma.
To review existing literature on the potential role of trauma in DFSP development.
To explore the possible mechanisms linking trauma to DFSP pathogenesis.

Main Methods:

Case report presentation.
Comprehensive literature review on dermatofibrosarcoma protuberans and trauma.
Analysis of potential immunopathologic pathways.

Main Results:

A case of DFSP associated with blunt trauma to the back is documented.
Literature suggests both genetic mutations and trauma may contribute to DFSP.
The exact mechanism of trauma-induced DFSP remains unclear but may involve chronic inflammation.

Conclusions:

Trauma may be a contributing factor in the development of dermatofibrosarcoma protuberans.
Further research is needed to elucidate the cellular mechanisms linking trauma and DFSP.
Understanding this relationship could inform future prevention or treatment strategies.