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Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
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Related Experiment Video

Updated: Dec 10, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Short-term refractive and ocular parameter changes after topical atropine.

Min-Chieh Ho1,2, Yi-Ting Hsieh1,3, Elizabeth P Shen1,2

  • 1Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Hualien, Taiwan.

Taiwan Journal of Ophthalmology
|September 3, 2020
PubMed
Summary
This summary is machine-generated.

Short-term atropine eye drops caused hyperopic shifts in most children, with axial length shortening and anterior chamber deepening. Some experienced myopic shifts due to transient axial elongation, suggesting sustained atropine treatment for myopia control.

Keywords:
Anterior chamber depthatropineaxial lengthcycloplegiarefraction

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Area of Science:

  • Ophthalmology
  • Pediatric eye care
  • Myopia research

Background:

  • Atropine is widely used for myopia control in children.
  • Understanding short-term ocular changes is crucial for treatment guidance.

Purpose of the Study:

  • To investigate short-term changes in refractive error and ocular parameters after cycloplegia with atropine.
  • To analyze correlations between these changes.

Main Methods:

  • Prospective clinical trial involving 96 children (mean age 8.5 years).
  • Measurements included spherical equivalent refractive error (SER), axial length (AL), mean keratometric value (mean-K), anterior chamber depth (ACD), and intraocular pressure (IOP) at baseline and 1 week post-atropine (0.125%).
  • Correlations analyzed using multiple linear regression.

Main Results:

  • Mean AL decreased by 0.016 mm and mean ACD increased by 0.58 mm (p<0.0001).
  • 85% of eyes showed emmetropic or hyperopic shifts; 15% showed myopic shifts.
  • Hyperopic shifts correlated with AL shortening and ACD deepening; myopic shifts correlated with transient AL elongation.

Conclusions:

  • Short-term atropine use primarily induces hyperopic shifts via AL shortening and ACD deepening.
  • Transient AL elongation can cause myopic shifts in a subset of patients, not invalidating atropine's role in myopia control.
  • Clinicians may consider sustained atropine treatment before exploring alternative myopia control strategies.