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Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane

Bhoomika Mathur1, Waqar Arif2, Megan E Patton1

  • 1Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

JHEP Reports : Innovation in Hepatology
|September 3, 2020
PubMed
Abstract

Keywords:
AH, alcoholic hepatitisALT, alanine aminotransferaseAPAP, acetaminophenAST, aspartate aminotransferaseBile acidsCA, cholic acidCAR, constitutive androstane receptorCholestasisCytochrome p450DKO, double knockoutDrug metabolismFXRKO, FXR knockoutFxr, farnesoid X receptorGGT, gamma-glutamyl transferaseGSH, glutathione disulphideLiver diseasesNAPQI, N-acetyl-p-benzoquinone imineNASH, non-alcoholic steatohepatitisNuclear receptorsPCN, pregnenolone 16 alpha-carbonitrilePHx, partial hepatectomyPXR, pregnane X receptorSHPKO, SHP knockoutShp, small heterodimer partnerTranscriptomicsWT, wild type

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