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Exercise and the immune response.

D Keast1, K Cameron, A R Morton

  • 1Department of Microbiology, University of Western Australia, Nedlands.

Sports Medicine (Auckland, N.Z.)
|April 1, 1988
PubMed
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Intense exercise may temporarily suppress the immune system, increasing infection risk in athletes. This immune suppression is linked to changes in lymphocytes and potential overtraining.

Area of Science:

  • Immunology
  • Exercise Physiology
  • Sports Medicine

Background:

  • Infectious diseases are increasingly linked to decreased athletic performance.
  • The immune system, comprising nonspecific and specific components, defends against infections.
  • Adaptive immunity, through antibody-mediated and cell-mediated responses, provides long-term immunity.

Purpose of the Study:

  • To investigate the impact of exercise on immune system cells and function.
  • To examine the relationship between exercise protocols and immune system modifications.
  • To explore the potential for temporary immune suppression following strenuous training.

Main Methods:

  • Mobilization of peripheral blood lymphocytes during exercise.
  • In vitro testing of lymphocyte responsiveness to mitogens.

Related Experiment Videos

  • Analysis of hormonal influences on immune cell function.
  • Monitoring of leukocyte populations and T4/T8 lymphocyte ratios.

    • Main Results:

    • Exercise mobilizes large numbers of lymphocytes.
    • In vitro tests suggest temporary impaired lymphocyte response to mitogens.
    • Hormonal factors and muscle-derived products influence immune cell activity.
    • Significant variations in circulating leukocyte populations observed, including potential reduction in T4/T8 lymphocyte ratio.

    Conclusions:

    • Strenuous exercise may lead to temporary immune suppression.
    • Reduced T4/T8 lymphocyte ratio may correlate with altered lymphocyte responsiveness.
    • Temporary immune suppression post-exercise could increase susceptibility to infection.
    • Overtraining may be a contributing factor to exercise-induced immune suppression.