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Updated: Dec 10, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Identifying bifurcated paths with differential function impact in glioblastomas evolution.

Yong Zhang¹, Aimin Xie¹, Fei Quan¹

¹College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.

International Journal of Cancer

|September 3, 2020

Summary

This summary is machine-generated.

This study reveals four key bifurcated evolutionary paths in glioblastoma (GBM), impacting genome instability and patient survival. These findings offer new avenues for glioblastoma patient stratification and prognosis prediction.

Keywords:

GBM bifurcated path copy number alteration differential function impact evolutionary trajectories

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Last Updated: Dec 10, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

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Published on: September 13, 2022

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Area of Science:

Oncology
Genetics
Evolutionary Biology

Background:

Cancer evolution is characterized by bifurcated trajectories with varying outcomes.
The existence and nature of such bifurcated paths in glioblastoma (GBM) remain largely unexplored.

Purpose of the Study:

To investigate and identify distinct evolutionary trajectories in glioblastoma.
To determine the impact of these evolutionary paths on clinical outcomes and tumor microenvironment.

Main Methods:

Analysis of clonal status and temporal order of cancer driver events in 385 GBM samples.
Construction of a population-level temporal map of GBM evolutionary trajectories.
Investigation of differential impacts on clinical outcomes, telomerase activity, and immune profiles.

Main Results:

Identification of four key bifurcated paths originating from chromosome 10 copy number loss (10 loss).
These paths diverge with subsequent events like chromosome 19 copy number gain (19 gain) or losses on chromosomes 13q, 15q, 6q, and 16q.
Significant differences in genome instability, telomerase activity, immune activity, and immune cell infiltration were observed across these paths.

Conclusions:

This study is the first to identify four key bifurcated evolutionary paths in glioblastoma.
These distinct paths significantly influence tumor progression, immune microenvironment, and patient survival.
The identified bifurcated paths hold potential for patient stratification and improved prognosis prediction in GBM.