Population genetic study of a Peruvian population using human identification STRs

Area of Science:

• Forensic Genetics
• Population Genetics
• Human Identification

Background:

• Accurate human identification relies on robust population-specific genetic data.
• Understanding genetic diversity is crucial for forensic applications.
• Latin American populations require detailed genetic profiling for identification.

Purpose of the Study:

• To establish allele frequencies for a Peruvian population.
• To evaluate the efficacy of GlobalFiler and VeriFiler Express kits for human identification.
• To assess genetic distances between Peruvian and other Latin American populations.

Main Methods:

• Analysis of 601 unrelated individuals from Peru.
• Utilized GlobalFiler Express (400 individuals) and VeriFiler Express (201 individuals) kits.
• Determined allele frequencies, power of discrimination (PD), and probability of exclusion (PE) for various loci.
• Calculated Fst genetic distances to compare with other Latin American populations.

Main Results:

• SE33 locus showed the highest power of discrimination (0.9851) with 31 alleles.
• D22S1045 locus was the least polymorphic (0.75810) with 11 alleles.
• Combined power of discrimination exceeded 0.9999999999.
• Shortest Fst genetic distance (0.004) was observed with Bolivian and other Peruvian populations.

Conclusions:

• The study provides essential allele frequency data for Peruvian populations, supporting human identification.
• The analyzed kits demonstrate high discriminatory power for forensic applications in this region.
• Genetic data reveals close relationships between Peruvian, Bolivian, and Venezuelan populations.