Target cell-substratum interaction. II. Complement-dependent antibody-induced inhibition of adherence

When trypsinized cells were treated with alloantibody and complement they initially adhered to their substratum, then detached. Specific cytolysis did not occur. In addition to demonstrating an immunologically mediated reaction, this phenomenon has permitted the development of a new, simple, rapid assay for alloantibody that does not require a cytolytic reaction.