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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Updated: Dec 10, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Musculoskeletal Conditions in Patients With Diabetes: A Narrative Review.

Dylan Shafer, Jake Gooing, Vincent Lee

    The Journal of the American Osteopathic Association
    |September 3, 2020
    PubMed
    Summary

    Diabetes mellitus (DM) is linked to many musculoskeletal (MSK) conditions. This review highlights common MSK disorders in DM patients, updating healthcare professionals on these prevalent issues.

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    Area of Science:

    • Endocrinology
    • Rheumatology
    • Public Health

    Background:

    • Diabetes mellitus (DM) is a global multisystem disease.
    • Vascular and cardiac complications of DM are extensively researched.
    • Musculoskeletal (MSK) conditions in DM patients are understudied.

    Purpose of the Study:

    • To analyze the prevalence of common MSK disorders in patients with DM.
    • To review current literature on MSK conditions associated with DM.
    • To update healthcare professionals on DM-related MSK issues.

    Main Methods:

    • Cross-sectional study analysis.
    • Comprehensive literature review.
    • Synthesis of existing research.

    Main Results:

    • Identified several common MSK disorders prevalent in DM patients.
    • Highlighted the association between DM and various MSK conditions.
    • Provided an updated overview of MSK manifestations in DM.

    Conclusions:

    • MSK conditions are a significant, often overlooked, comorbidity in diabetes mellitus.
    • Increased awareness and research into DM-related MSK conditions are warranted.
    • Healthcare professionals should consider MSK screening in diabetic patients.