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Colloids03:22

Colloids

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer.

Francis Kamau Mwiiri1, Rolf Daniels1

  • 1Department of Pharmaceutical Technology, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.

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Summary

This study optimized birch bark extract (TE) colloidal dispersions using hydrogenated phospholipids for wound dressings. Optimized formulations achieved smaller particle sizes and demonstrated synergistic interactions for enhanced stability.

Keywords:
birch bark extractcolloidal dispersionshigh-pressure homogenizationinterfacial rheologyphospholipidssunflower oil

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry
  • Biomaterials Engineering

Background:

  • Aqueous colloidal dispersions are crucial for developing advanced drug delivery systems.
  • Birch bark extract (TE) possesses therapeutic properties but requires effective formulation for applications like wound dressings.
  • Hydrogenated phospholipids (Phospholipon 90H) are known stabilizers for colloidal systems.

Purpose of the Study:

  • To investigate the formulation and processing of aqueous colloidal dispersions containing birch bark extract (TE) and hydrogenated phospholipids (Phospholipon 90H).
  • To evaluate the impact of phospholipid content on particle size distribution and interfacial properties.
  • To explore the potential of these dispersions for electrospun wound dressing applications.

Main Methods:

  • Two-stage homogenization process for dispersion preparation.
  • Particle size analysis to determine distribution and average size.
  • Dynamic interfacial tension and viscoelasticity measurements using a profile analysis tensiometer (PAT) and oscillating drop technique.
  • Confocal Raman microscopy (CRM) for component localization.

Main Results:

  • The two-stage homogenization resulted in bimodal particle size distribution, significantly influenced by phospholipid content (p < 0.0001).
  • Average particle size was reduced from approximately 4 µm to 400 nm with optimized formulation.
  • Phospholipids significantly reduced interfacial tension, with a further decrease observed when combined with TE, indicating synergistic interaction.
  • Interfacial elasticity and viscosity increased, suggesting stable film formation at the interface.
  • CRM confirmed preferential localization of TE in the oil phase and phospholipids at the interface.

Conclusions:

  • Optimized formulation of birch bark extract (TE) colloidal dispersions using hydrogenated phospholipids (Phospholipon 90H) is achievable.
  • The developed dispersions exhibit desirable particle size characteristics and interfacial properties for potential use in electrospun wound dressings.
  • A synergistic interaction between phospholipids and TE enhances dispersion stability.