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Updated: Dec 10, 2025
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[S100A8/A9 and periodontal inflammatory diseases]
1Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.
Calprotectin S100A8/A9, a key neutrophil protein, is linked to periodontal disease. This protein shows promise as a biomarker for diagnosis, monitoring, and predicting periodontitis.
Area of Science:
- Immunology
- Periodontology
- Biomarker Discovery
Background:
- Calprotectin S100A8/A9 is a major cytoplasmic protein in neutrophils.
- It plays significant roles in both intracellular and extracellular immuno-inflammatory responses.
- Emerging research highlights its association with the onset and advancement of periodontal inflammatory diseases.
Purpose of the Study:
- To review the clinical research on the relationship between S100A8/A9 and periodontal inflammatory diseases.
- To explore the potential of S100A8/A9 as a diagnostic and prognostic biomarker for periodontitis.
Main Methods:
- Literature review of clinical studies.
- Analysis of research on S100A8/A9 in the context of periodontal inflammation.
Main Results:
- S100A8/A9 is closely implicated in the initiation and progression of periodontal inflammatory diseases.
- The protein is being investigated for its utility in diagnosing periodontitis.
- S100A8/A9 may help monitor inflammatory activity, assess treatment outcomes, and predict individual susceptibility to periodontitis.
Conclusions:
- Calprotectin S100A8/A9 is a potential new biomarker for periodontal inflammatory diseases.
- Further research is warranted to fully establish its clinical applications in periodontitis management.
