Related Experiment Video
Updated: Dec 10, 2025
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[S100A8/A9 and periodontal inflammatory diseases]
1Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.
Insights
Calprotectin S100A8/A9, a key neutrophil protein, is linked to periodontal disease. This protein shows promise as a biomarker for diagnosis, monitoring, and predicting periodontitis.
Area of Science:
- Immunology
- Periodontology
- Biomarker Discovery
Background:
- Calprotectin S100A8/A9 is a major cytoplasmic protein in neutrophils.
- It plays significant roles in both intracellular and extracellular immuno-inflammatory responses.
- Emerging research highlights its association with the onset and advancement of periodontal inflammatory diseases.
Purpose of the Study:
- To review the clinical research on the relationship between S100A8/A9 and periodontal inflammatory diseases.
- To explore the potential of S100A8/A9 as a diagnostic and prognostic biomarker for periodontitis.
Main Methods:
- Literature review of clinical studies.
- Analysis of research on S100A8/A9 in the context of periodontal inflammation.
Main Results:
- S100A8/A9 is closely implicated in the initiation and progression of periodontal inflammatory diseases.
- The protein is being investigated for its utility in diagnosing periodontitis.
- S100A8/A9 may help monitor inflammatory activity, assess treatment outcomes, and predict individual susceptibility to periodontitis.
Conclusions:
- Calprotectin S100A8/A9 is a potential new biomarker for periodontal inflammatory diseases.
- Further research is warranted to fully establish its clinical applications in periodontitis management.
Abstract:
Calprotectin S100A8/A9, a heterodimer composed of S100A8 and S100A9, is the main component of cytoplasmic proteins in neutrophils. It plays multiple roles in the immuno-inflammatory reactions intracellularly and extracellularly. Recent studies find that S100A8/A9 is closely related with the initiation and progression of periodontal inflammatory diseases. S100A8/A9 is expected to be a new biomarker for diagnosing periodontal inflammatory diseases, monitoring inflammatory activities in patients with periodontitis, evaluating the outcome of periodontal treatments and predicting the susceptibility of individual patient to periodontitis. In this literature review, we summarize the clinical research progress on the relation between S100A8/A9 and periodontal inflammatory diseases.
