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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Two new homoisoflavones from Portulaca oleracea L. and their activities
Yang Duan1, Zheming Ying2, Mingbo Zhang1
1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, PR China.
Abstract:
Two new compounds, identified as 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one (1), named oleracone J and 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one (2), named oleracone K, were isolated from Portulaca oleracea L., and the structures of them were determined by spectroscopy, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionisation time-of-flight mass spectrometry. The two compounds have scavenging activities in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, with IC50 values of 18.34, 23.92 μM, and anticholinesterase activities with IC50 values of 59.08, 67.89 μM, respectively.
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