Related Experiment Video
Updated: Dec 10, 2025
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses
Patrick O'Connell1, Yasser A Aldhamen1
1Department of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University , East Lansing, MI, USA.
Abstract:
The deadly pandemic caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the greatest threats humanity has faced in the last century. Infection with this easily transmissible virus can run the gamut from asymptomatic to fatal, and the disease caused by SARS-CoV-2 has been termed Coronavirus Disease 2019 (COVID-19). What little research that has already been conducted implicates pathological responses by the immune system as the leading culprit responsible for much of the morbidity and mortality caused by COVID-19. In this review we will summarize what is currently known about the systemic immune response to SARS-CoV-2 and potential immunotherapeutic approaches.
Insights
The novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), causes COVID-19. Pathological immune responses are linked to COVID-19 severity, prompting research into immunotherapeutic strategies.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic.
- COVID-19 presents a spectrum of illness, from asymptomatic to fatal.
- Immune system dysregulation is implicated in COVID-19 morbidity and mortality.
Purpose of the Study:
- To review the current understanding of the systemic immune response to SARS-CoV-2.
- To explore potential immunotherapeutic strategies for COVID-19.
Main Methods:
- Literature review of existing research on SARS-CoV-2 immunology.
- Synthesis of findings on immune system involvement in COVID-19 pathogenesis.
Main Results:
- The systemic immune response to SARS-CoV-2 is complex and contributes significantly to disease severity.
- Specific immune pathways and cellular responses are identified as key players in COVID-19 pathology.
Conclusions:
- Understanding the immune response to SARS-CoV-2 is crucial for developing effective treatments.
- Immunotherapies targeting pathological immune responses show promise for managing COVID-19.
More Related Videos
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
Related Concept Videos
01:21Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
01:29Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
01:38What is the Immune System?
01:36Humoral Immune Responses
01:40Cell-mediated Immune Responses
01:22Introduction to Lymphatic and Immune System
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...