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Related Experiment Videos

Long-term bepridil monotherapy for angina pectoris.

M K Sharma1, W Voyles, R Prasad

  • 1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

The American Journal of Cardiology
|June 1, 1988
PubMed
Summary

Bepridil effectively treated stable angina pectoris in men, significantly reducing angina frequency and nitroglycerin use over 24 months. This long-term monotherapy demonstrated sustained efficacy with manageable side effects.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Stable angina pectoris requires effective long-term management.
  • Bepridil is a calcium channel blocker with potential antianginal properties.

Purpose of the Study:

  • To evaluate the long-term efficacy and safety of bepridil as a once-daily monotherapy for stable angina pectoris.

Main Methods:

  • A 24-month open-label study in 19 men with stable angina.
  • Patients received bepridil (100-400 mg/day) after placebo-controlled titration.
  • Efficacy assessed via patient diaries and treadmill exercise tests every 3 months.

Main Results:

  • Significant reductions in weekly angina frequency (10.3 to 1.8) and nitroglycerin use (5.0 to 1.4) after 3 months, sustained for 24 months.

Related Experiment Videos

  • Significant increases in walking time to angina (5.2 to 7.9 min) and total exercise time (7.1 to 8.8 min).
  • Mild-to-moderate neurologic and gastrointestinal side effects observed; no significant ventricular dysrhythmias detected.

    • Conclusions:

    • Once-daily bepridil monotherapy is effective and well-tolerated for long-term management of stable angina pectoris.
    • Sustained improvements in exercise tolerance and symptom reduction were observed.
    • QTc interval prolongation occurred but did not correlate with adverse cardiac events or necessitate treatment discontinuation.