Related Experiment Video
Updated: Dec 10, 2025
Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview
Annelies VAN Beeck1, Michiel VAN DE Sande2, Veroniek VAN Praag2
1University Hospital Antwerp, Antwerp, Belgium annelies.vanbeeck@gmail.com.
Aim:
This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy.
Patients And Methods:
A retrospective case series of all patients with leiomyosarcoma, surgically treated between 2000 and 2015 and a minimum follow-up of 2 years, was drawn from institutional databases in Belgium and the Netherlands. Postoperative complications were reported with the Radiation Therapy Oncology Group (RTOG) and the Henderson classification.
Results:
Seventy-five patients were operated on, of whom 47 underwent (neo)adjuvant therapy. Infection was observed in 11 patients, seven associated with (neo)adjuvant radiotherapy. Dermatological complaints were observed in 26 patients, 10 associated with (neo)adjuvant radiotherapy. Overall survival was 60%. Local recurrence occurred in 11 (15%) patients.
Conclusion:
This study describes favourable clinical outcome following (neo)adjuvant radiotherapy. In the future, larger databases on leiomyosarcoma should enhance the power of these findings and define the benefits of adjuvant therapy in leiomyosarcoma.
