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Updated: Dec 10, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in
Yuting Li1, Renzhe Cui1, Keyang Liu1,2
1Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine.
Insights
Endothelial dysfunction, a condition affecting blood vessel lining, is linked to a higher prevalence of chronic kidney disease (CKD) in Japan. This study highlights the importance of vascular health in kidney function.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Vascular Biology
Background:
- Chronic kidney disease (CKD) presents a significant cardiovascular burden.
- Endothelial dysfunction is implicated in both CKD progression and cardiovascular damage.
Purpose of the Study:
- To investigate the association between endothelial dysfunction and CKD prevalence.
- Focus on the general Japanese population.
Main Methods:
- Cross-sectional study of 1042 participants (aged 30-81) in Japan.
- Assessed endothelial function using brachial artery flow-mediated dilation (%FMD).
Main Results:
- A significant trend (p=0.02) showed increased CKD odds with lower %FMD quartiles.
- In individuals not using antihypertensive medication, lower %FMD was associated with higher CKD odds (p for trend=0.01).
- Each one-point decrease in %FMD correlated with increased CKD risk (OR 1.16, p=0.01).
Conclusions:
- Endothelial dysfunction is associated with a higher prevalence of CKD.
- Findings suggest vascular health is a key factor in kidney disease risk in the Japanese population.
Aims:
Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relationship between endothelial dysfunction and the prevalence of CKD in the general Japanese population.
Methods:
We conducted a cross-sectional study of 1042 men and women aged 30-81 years in two communities under the Circulatory Risk in Communities Study between 2013 and 2017. Endothelial function was evaluated by percent change of brachial artery flow-mediated dilation (%FMD) before and after the cuff inflation.
Results:
Among the total 1042 participants, there were 62 cases of CKD (~6%). The multivariable odds ratios (ORs) (95% confidence intervals [CIs]) of CKD according to quartiles of %FMD were 2.02 (0.68-5.99), 3.56 (1.27-9.94), and 3.14 (1.10-8.93) for the third to lowest quartile compared with the highest %FMD quartile; p for trend=0.02. The respective multivariable ORs (95% CIs) of CKD in subjects without antihypertensive medication use (39 cases among 886 subjects) were 1.83 (0.46-7.33), 3.41 (0.92-12.61), and 4.60 (1.22-17.31); p for trend=0.01, and that for one-point decrement in %FMD was 1.16 (1.00-1.35); p for interaction with the status of antihypertensive medication use was 0.12.
Conclusions:
Our cross-sectional study suggested the relationship between endothelial dysfunction and the higher prevalence of CKD in the general Japanese population.
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