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Updated: Nov 21, 2025

Author Spotlight: Enhancing Coronary Artery Revascularization
Published on: September 15, 2023
18-Year Follow-Up After Coronary Stenting for Left Main Coronary Artery Lesions
Junqin Bai1, Zhichao Dong1, Lifei Pan1
1Department of Cardiology, First Affiliated Hospital, Dalian Medical University.
Insights
Radiation-induced coronary artery disease (RCAD) treatment outcomes remain understudied. This case highlights successful coronary stenting in a patient with radiation-induced left main coronary artery lesions, despite neointimal proliferation.
Area of Science:
- Cardiology
- Oncology
- Radiation Oncology
Background:
- Radiation-induced coronary artery disease (RCAD) treatment outcomes require further investigation.
- Patients with RCAD often lack traditional cardiovascular risk factors.
- Mediastinal radiation therapy for lymphoma can lead to coronary artery lesions.
Observation:
- The patient had received mediastinal radiation therapy (RT) at age 26 for Hodgkin lymphoma.
- Initial treatment involved LMCA stenting, followed by balloon angioplasty at age 38 for in-stent stenosis.
Findings:
- At age 51, the patient reported no chest pain, with coronary angiography showing no new lesions.
- Optical coherence tomography revealed mild neointimal proliferation, calcific plaque, and uncovered stent struts, indicating residual disease despite clinical improvement.
Implications:
- Coronary stenting can be a viable treatment option for radiation-induced coronary artery disease (RCAD) lesions.
- This case provides valuable insights into the long-term management and potential complications of stenting in RCAD patients.
Abstract:
The current treatment of radiation-induced coronary artery disease (RCAD) is comparable to that of generic coronary artery disease (CAD); however, the outcomes of these treatment measures have not been fully examined in RCAD. A 33-year-old woman, without conventional cardiovascular risk factors, presented with left main coronary artery (LMCA) lesions. At the age of 26, she received mediastinal radiation therapy (RT) to treat mixed cellularity Hodgkin lymphoma. One BiodivYsio 3.5 × 18 mm stent was implanted at the LMCA site. At the age of 38, the patient was treated by balloon dilatation because of approximately 50% in-stent stenosis. At the last follow-up in February 2018, when the patient was 51 years old, she no longer complained of chest pain. Coronary angiography showed no de novo or in-stenosis lesions, although optical coherence tomography showed mild neointimal proliferation, calcific plaque, small ruptured intima, and several uncovered struts. The experience of treating this case may shed some light on coronary stenting in coronary lesions caused by RCAD.
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