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Related Experiment Videos

T-cell-rich B-cell lymphoma.

A D Ramsay1, W J Smith, P G Isaacson

  • 1Department of Histopathology, University College, London, England.

The American Journal of Surgical Pathology
|June 1, 1988
PubMed
Summary

This study details five B-cell lymphoma cases that initially mimicked T-cell lymphoma. Advanced immunohistochemistry identified B-cells as the neoplastic population, despite T-cell morphology.

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Leukemia·2010

Area of Science:

  • Hematology
  • Oncology
  • Immunopathology

Background:

  • B-cell lymphomas can present with morphological and immunophenotypic features resembling T-cell neoplasms.
  • Accurate diagnosis is crucial for appropriate treatment and patient outcomes.

Purpose of the Study:

  • To describe cases of B-cell lymphoma that mimic T-cell lymphoma.
  • To highlight the diagnostic challenges and the utility of advanced immunohistochemical techniques.

Main Methods:

  • Morphological and histological examination of lymphoma tissues.
  • Immunohistochemistry on frozen and paraffin-embedded samples using lineage-specific markers.
  • Immunoglobulin immunostaining and analysis of lineage-related monoclonal antibodies.
  • Genetic analysis for clonality and gene rearrangement.

Main Results:

  • Five cases exhibited features of T-cell lymphoma, including pleomorphic and lymphocytic lymphoma subtypes.
  • Initial immunohistochemistry showed a predominant T-cell population with <10% B-cells.
  • Advanced techniques confirmed B-cells as the neoplastic component, despite a reactive T-cell infiltrate.
  • Genetic analysis did not reveal clear clonality in T-cells or detectable rearrangement in B-cells.

Conclusions:

  • Certain B-cell lymphomas can be morphologically and immunologically mistaken for T-cell lymphomas.
  • Careful and comprehensive immunohistochemical analysis, including immunoglobulin staining and specific monoclonal antibodies, is essential for correct diagnosis.
  • The presence of a reactive T-cell response can obscure the underlying B-cell neoplasm.

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