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Updated: Dec 10, 2025

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Microfluidics for interrogating live intact tissues.

Lisa F Horowitz1, Adán D Rodriguez1, Tyler Ray2

  • 1Department of Bioengineering, University of Washington, Seattle, WA 98195 USA.

Microsystems & Nanoengineering
|September 4, 2020
PubMed
Summary
This summary is machine-generated.

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Microfluidics precisely controls the tissue microenvironment for live tissue studies. This technology enhances drug testing and diagnostic accuracy, especially with scarce tissue samples.

Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Microfluidics

Background:

  • The tissue microenvironment significantly influences tissue function.
  • Precise control over the microenvironment is crucial for various biological and clinical applications.
  • Microfluidics enables manipulation and analysis of microenvironments in live tissues.

Purpose of the Study:

  • To review the applications of microfluidics in studying the physiology and pathophysiology of intact live tissues.
  • To categorize microfluidic approaches for studying live tissues as in vitro or in vivo.
  • To highlight the potential of microfluidics for functional measurements on intact tissues.

Main Methods:

  • Review of existing literature on microfluidic systems for live tissue studies.
Keywords:
EngineeringMaterials science

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  • Categorization of microfluidic applications into in vitro and in vivo studies.
  • Discussion of microfluidic device integration with live tissues.

    • Main Results:

    • Microfluidics allows precise stimulation, manipulation, and analysis of the tissue microenvironment.
    • Applications include analytical sensors, drug testing on biopsy specimens, and biological experiments.
    • Microfluidic systems facilitate multiplexing for increased testing accuracy and reduced costs.
    • Both in vitro and in vivo approaches using microfluidics are discussed.

    Conclusions:

    • Microfluidics is an invaluable tool for studying live tissues at sub-millimeter scales.
    • These systems enable direct functional measurements on intact tissues, such as drug responses and secretion analysis.
    • Microfluidic technologies promise to advance diagnostics and biological research by providing unprecedented control and insight into tissue behavior.