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Hyperspectral Imaging and the Retina: Worth the Wave?
Sophie Lemmens1,2,3, Jan Van Eijgen1,2,3, Karel Van Keer1,2
1University Hospitals UZ Leuven, Department of Ophthalmology, Leuven, Belgium.
Translational Vision Science & Technology
|September 4, 2020
Summary
Hyperspectral imaging shows promise for retinal oximetry and diagnosing eye diseases. However, its clinical application is limited by a lack of large-scale validation studies, warranting further research.
Area of Science:
- Biomedical imaging
- Ophthalmology
- Physiological and clinical processes
Background:
- Hyperspectral imaging (HSI) offers advanced spectral information for biomedical applications.
- A systematic review of retinal HSI literature is currently lacking.
- This study provides the first systematic overview of retinal HSI.
Purpose of the Study:
- To systematically review scientific literature on retinal hyperspectral imaging.
- To identify and summarize existing HSI technologies and their applications in ophthalmology.
- To assess the current state and future potential of retinal HSI.
Main Methods:
- Systematic literature review conducted according to PRISMA Statement 2009 criteria.
- Searches performed in four major bibliographic databases: Medline, Embase, Cochrane Database of Systematic Reviews, and Web of Science.
- Narrative synthesis and summary tables of findings due to methodologic heterogeneity.
Main Results:
- Fifty-six articles met the review criteria, reporting diverse HSI techniques (e.g., tunable filters, laser sources, prisms, gratings, CT, fiber optics).
- Retinal oximetry emerged as a primary application, yielding valuable diagnostic and monitoring information for ocular diseases.
- Despite promising results in smaller studies, no HSI applications have reached widespread clinical practice.
Conclusions:
- Retinal hyperspectral imaging applications in ophthalmology are nascent.
- Current limitations include the need for larger validation studies to confirm clinical utility.
- Further advanced research is essential to realize the full clinical potential of HSI in ophthalmology.
