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Updated: Dec 10, 2025

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Published on: October 27, 2020
Transforming growth factor beta signaling functions during mammalian kidney development
Mihai G Dumbrava1, Jon L Lacanlale1,2, Christopher J Rowan1
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 686 Bay Street, Toronto, M5G 0A4, Canada.
Abstract:
Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development and how dysregulation of TGFβ signaling contributes to the pathogenesis of kidney malformation.
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