Related Experiment Video

Updated: Dec 10, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.8K

STAT3 transcription factor as target for anti-cancer therapy

Aliaa M Mohassab1, Heba A Hassan2, Dalia Abdelhamid1

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.

Pharmacological Reports : PR
|September 4, 2020
PubMed

Insights

Signal transducer and activator of transcription 3 (STAT3) plays a key role in cancer progression. This review discusses drugs that inhibit STAT3 activation for effective cancer therapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • Signal transducer and activator of transcription (STAT) proteins are crucial for cellular functions.
  • STAT3 is implicated in various cancer hallmarks, including proliferation, survival, and metastasis.
  • STAT3 activation is a significant therapeutic target in oncology.

Purpose of the Study:

  • To review and discuss drugs that inhibit STAT3.
  • To highlight the therapeutic applications of STAT3 inhibitors in different cancer types.

Main Methods:

  • Literature review of scientific articles and clinical studies.
  • Analysis of drug mechanisms targeting STAT3.
  • Summary of current and emerging STAT3 inhibitors in cancer treatment.

Main Results:

  • STAT3 signaling is dysregulated in numerous cancers.
  • Various pharmacological agents targeting STAT3 have demonstrated efficacy.
  • STAT3 inhibitors are utilized in treating leukemia, melanoma, colon, and renal cancers.

Conclusions:

  • Inhibition of STAT3 is a promising strategy for cancer treatment.
  • Further research into STAT3 inhibitors may lead to novel therapeutic approaches.
  • STAT3-targeted therapies offer potential for improved patient outcomes in oncology.
Keywords:
CancerLeukemiaMelanomaSTAT3

More Related Videos

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

15.3K
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

7.3K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.5K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.2K