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Updated: Dec 10, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Hepatocellular adenoma: update 2020]
Élodie Romailler1, Sabine Schmidt Kobbe2, Darius Moradpour1
1Service de gastroentérologie et d'hépatologie, CHUV et Université de Lausanne, 1011 Lausanne.
Abstract:
Hepatocellular adenomas (HA) are rare benign liver tumors known to affect mainly women of reproductive age taking oral contraception. They can be complicated by hemorrhage or malignant transformation to hepatocellular carcinoma, especially when the size of the lesion exceeds 5 cm. Magnetic resonance imaging is the most specific tool for the non-invasive characterization of HA. The discovery of mutations underlying different specific HA phenotypes has allowed the establishment of a molecular classification that modified the management of this pathology.

