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Updated: Dec 10, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

[Hepatocellular adenoma: update 2020].

Élodie Romailler¹, Sabine Schmidt Kobbe², Darius Moradpour¹

¹Service de gastroentérologie et d'hépatologie, CHUV et Université de Lausanne, 1011 Lausanne.

Revue Medicale Suisse

|September 4, 2020

Summary

This summary is machine-generated.

Hepatocellular adenomas (HA), rare liver tumors in women, can bleed or become cancerous. Molecular classification and MRI improve diagnosis and management of these benign liver lesions.

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Area of Science:

Hepatology
Oncology
Radiology

Background:

Hepatocellular adenomas (HA) are rare benign liver tumors primarily affecting women of reproductive age using oral contraceptives.
Complications include hemorrhage and malignant transformation to hepatocellular carcinoma, particularly for lesions >5 cm.
Accurate diagnosis is crucial for patient management.

Purpose of the Study:

To review the current understanding of hepatocellular adenomas.
To highlight the role of magnetic resonance imaging (MRI) in HA characterization.
To discuss the impact of molecular classification on HA management.

Main Methods:

Review of current literature on Hepatocellular Adenomas.
Emphasis on diagnostic capabilities of Magnetic Resonance Imaging (MRI).
Integration of molecular findings into classification systems.

Main Results:

MRI is the most specific non-invasive tool for HA characterization.
Discovery of mutations has led to distinct HA phenotypes.
A molecular classification system has been established.

Conclusions:

Molecular classification has significantly advanced the understanding and management of HA.
Non-invasive diagnosis using MRI is key.
Further research into HA subtypes and their clinical implications is warranted.