Allosteric Signal Amplification Sensing Using a Bisthiourea-Binaphthyl-Polythiophene Conjugate: A Positive Homotropic Allosterim Case
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Updated: Dec 10, 2025

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
Published on: February 18, 2014
Tomoaki Tsuchiya1, Gaku Fukuhara1,2
1Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
Abstract:
The development of signal amplification systems has attracted much attention and presents a highly challenging objective. Herein, we reveal the amplification processes using a newly synthesized bisthiourea-binaphthyl-polythiophene conjugate. The spectral data, behavior of supramolecular complexation, and thermodynamic parameters with calculation support comprehensively elucidated the factors that control the outcomes of the signal amplification. The present work provides a new perspective on functional chemosensors and an attractive alternative to conventional amplification systems.
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